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ea0026oc5.4 | Hormone metabolism and action | ECE2011

Adrenal melanocortin 2 receptor associated protein (MRAP) expression is regulated by ACTH and angiotensin II, whereas MRAP2 levels are associated with ACTH responsiveness

Hofland J , Delhanty P J , Steenbergen J , Hofland L J , van Koetsveld P M , van Nederveen F H , de Herder W W , Feelders R A , de Jong F H

Introduction: ACTH stimulates adrenocortical steroid production through the melanocortin 2 receptor (MC2R). MC2R trafficking and signaling depend on the melanocortin 2 receptor accessory protein (MRAP). The MRAP-homolog MRAP2 also transports the MC2R but prevents effective activation. We investigated expression of these components of the MC2R complex in human adrenal tissues in order to uncover novel regulatory mechanisms and their contribution to ACTH responsiveness.<p cl...

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ea0026p353 | Steroid metabolism | ECE2011

Activin A regulates local testosterone production and growth in prostate cancer through 17β-hydroxysteroid dehydrogenase

Hofland J , van Weerden W M , Steenbergen J , Dits N F J , Jenster G , de Jong F H

Introduction: Local androgen synthesis in prostate cancer (PC) could contribute to the development of castration-resistant PC (CRPC). Pathways controlling intratumoral steroidogenic enzyme expression in PC are unknown. Since activin has been implicated in regulation of PC growth and steroidogenic enzyme expression in other steroidogenic tissues, we investigated the effect of activin on intratumoral steroidogenesis in PC.Methods: Activin A effects and reg...

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Endocrine Abstracts

Adrenal melanocortin 2 receptor associated protein (MRAP) expression is regulated by ACTH and angiotensin II, whereas MRAP2 levels are associated with ACTH responsiveness

Activin A regulates local testosterone production and growth in prostate cancer through 17β-hydroxysteroid dehydrogenase

BiosciAbstracts